It’s hard to imagine from modern perspective, but if you could travel back in time and land in 1997 you would have arrived in a world without impotence pills! The discovery of Viagra in 1998 was a unique landmark for erectile dysfunction treatment, the moment of birth of impotence pills as we know them today. Unlike earlier medicines which were very uncomfortable to use and came with a vast array of potential side effects, modern impotence pills, pioneered by Viagra are simple, safe and easy to use and what’s more, they produce results by working together with the natural erection mechanism, making them much less aggressive in terms of their mechanism of action.

The most common impotence pills that you can read more about on our website include:

Box med Spedra 200 mg

What’s on this page?

How do these pills work?

Erectile dysfunction is, in most cases, caused by the narrowing of the blood vessels in the penis or the genital region, so the blood cannot get to the penis in the amount needed for gaining and maintaining an erection. In addition, this condition is usually accompanied by a higher concentration of PDE5 enzyme in the organism which plays a role in driving the blood away from the penis by interfering with the cGMP cyclic nucleotide. This compound relaxes the smooth muscle tissues, contributing to the increased blood flow, and by extension, gaining and maintaining an erection.

Impotence pills that fall within the category of PDE 5 inhibitors work by inhibiting the effects of the aforementioned enzyme and allowing the cGMP to do its magic. With this unique mechanism of action, drugs like Viagra, Cialis, Levitra and Spedra work in tandem with the natural mechanisms responsible for erection.

Which pill is the best?

The four PDE 5 inhibitors discussed above all work in a similar way, although they are differentiated by their active ingredients which are responsible for some differences and also for the fact that some of these medicines work better for some people than for others. So, while there is no answer to the question which impotence pill is the best, the question of which impotence pill will work best for you can be best answered by a doctor who will get familiar with the specifics of your condition. Bellow, you can find some general info regarding the differences between already mentioned impotence pills:

Medicine Active Ingredient Onset Time Duration
Viagra Sildenafil 30 minutes 4 hours
Cialis Tadalafil 30 minutes 36 hours
Levitra Vardenafil 15 minutes 5 hours
Spedra Avanafil <15 minutes 6 hours

Viagra, the famous “blue pill” is not only the longest in the market of all the mentioned, but is also most sold impotence pill globally. This fact usually contributes to a sense of safety and reliability that strongly influence men to give Viagra a try before any of the other impotence pills. With a medium onset of 30 minutes and effectiveness that lasts for around four or five hours, Viagra is most suitable for men who take it for relatively planned sex – typically, if you have a regular partner.

If you experience some of the side effects of sildenafil, Viagra’s active ingredient, you may want to try Levitra instead which is typically milder since its active ingredient, Vardenafil, is active at a much lower dose, making it less likely to produce unwanted side effects.

Pills with long-lasting effects

If you’re looking for an impotence pill that will produce long-lasting effects, then Cialis is sure to fulfil your expectations. The effectiveness that lasts for up to 36 hours is the core difference from much shorter lasting Viagra. However, this does not mean that you will have an erection lasting for as long – it means simply that the medicine will contribute to gaining and maintaining an erection if you’re sexually stimulated within 36 hours after consuming Cialis.

This medicine is the best solution for “one pill for the whole weekend” approach and is especially suitable if you don’t want to plan the exact time when you might have sex. For many men, this is a great relief and it can also help with psychological impotence problems since you don’t have to worry about when you should take a pill.

Pills with a quick onset

If you find Viagra’s 30 minutes onset far too long for your taste, Spedra might be what you need to get your sex life back on track. Spedra is relatively new impotence pills which, just like Levitra, acts very quickly, almost immediately, making you ready for action almost as soon as you take it.

Viagra vs Sildenafil

You might have noticed that since recently, sildenafil is also available on the market, however, here you have also read that sildenafil is the active ingredient of Viagra. So, what’s all that about?

The bottom line is – there is no difference between these two types of pills, aside from the brand name itself. In 2013, the patent expired on Viagra, making it legal for other pharmaceutical companies to manufacture the generic version. So, Sildenafil is simply generic Viagra, sharing the same effects and ingredients with the branded version.

Should I be extra careful?

You should avoid using PDE 5 inhibitors if you are taking other medicines that contain nitrite. If you’re unsure about the ingredients of other medicaments you might be using always consult with your doctor. Other cases include low or dangerously high blood pressure (hypertension). Recent stroke or heart attack are also factors which should be taken into consideration.

Are there any non-prescription pills?

All PDE5 inhibitors can be obtained only with a prescription from a certified medical professional. However, you can find some of the so-called “potency drugs” which are available online without a prescription. However, most of these can be classified either as herbal remedies or aphrodisiacs whose effects have not been medically proven and tested, meaning there is no scientific consensus on their efficiency or safety. For some, these can produce strong placebo effect and have been noticed to produce results in cases of psychological impotence. However, these remedies aren’t classified as medicines. If you’re looking for a certified, clinically tested and reliable solution, you will need a prescription.

If you’re worried about talking to a doctor about this very awkward and unpleasant topic, the good news is that you can get impotence pills from various online clinics without a prior prescription. You’ll simply have to fill in a questionnaire detailing your present condition and medical history which the doctor will then use to determine if you’re eligible for treatment and which impotence pill is the right for you – simple, and without that awkward face to face conversation!