Kliovance is a combined hormonal replacement therapy (or HRT for short) that is available in the form of a standard tablet. Based on synthetic versions of oestrogen and progesterone, namely, estradiol and norethisterone acetate, respectively, Kliovance is similar in its composition to many other HRTs available on the UK market. However, what makes it unique is the lower concentration of active ingredients, making Kliovance especially suitable for women who are more sensitive to hormones than the majority.

What’s on this page?

Developed and marketed by Novo Nordisk pharmaceutical company, Kliovance is commonly prescribed in the UK for alleviation of symptoms of menopause in women who have not had surgically removed the womb and who have not had a period for a minimum of 12 months.

How does Kliovance mitigate menopausal symptoms?

At root of all problems and issues associated to menopause is the hormonal imbalance brought on by the decreasing levels of oestrogen just prior to and following the final ovulation. With that in mind, it comes as no surprise that HRTs aim to mitigate the oestrogen deficiency with a synthetic bioequivalent. Precisely this is the task of estradiol, one of the active ingredients of Kliovance.

However, it is well known that uncontrolled rise in oestrogen levels can contribute to thickening of the uterine wall, thus increasing the risk of endometrial cancer. For women who have had their womb removed, this is not a problem and they can use oestrogen-only HRTs without any problems. However, for others, this can be very risky, so oestrogen-only treatments will be supplemented with another medicine which contains synthetic progesterone tasked with keeping the oestrogen levels in check.

Alternatively, and as is the case with Kliovance and several other medications such as Kliofem, combined HRT can be prescribed – a medication that contains both oestrogen and progesterone equivalents. In this way, a single treatment will be able to both supplement falling oestrogen levels and ensure they never become dangerously high.

Can I buy Kliovance online in the UK?

Yes, it is possible to buy Kliovance online in the United Kingdom, but only if you have already been using this medication in the past. If it is your first time buying Kliovance, you will still have to consult with your doctor in person so he can assess your condition and suitability for using this medication. However, if you are simply looking to renew your prescription, the good news is that you can easily accomplish this without leaving the comfort of your home. You can simply visit your online clinic’s website and use the provided functionality to order the medication.

You will still be asked to fill in a medical questionnaire specifically designed in such a way to allow the doctor to correctly assess your suitability for the medication you are looking to purchase while allowing him or her to gain an in-depth insight in your medical profile and history. If the doctor agrees that you can use Kliovance safely, he will issue a prescription and order the medicine from a partner pharmacy, to have it delivered to the address you provided.

How is Kliovance used?

In order to ensure the best results when using this medication, you should always strictly adhere to the instructions provided by your prescriber. In addition to this, you should get familiar with the tips and guidelines contained in the official patient information leaflet that is issued within every Kliovance pack. By doing so, you will ensure the best possible results when using this medication while at the same time minimising the risk of side effects.

Below you will find some of the most general guidelines regarding the use of Kliovance. However, you should keep in mind that what follows is not supposed to be used as a substitute for the official patient information leaflet and the precise guidelines provided there.

  • Always use exactly as prescribed
  • The usual dose is one pill per day, taken at the same time
  • You will get the tablets in a calendar pack that will help you keep track of your treatment
  • Take the tablets whole, with water if needed and never crush, break or chew them
  • If you forget to take a pill, do so as soon as you remember, provided that it’s within 12 hours of when you were supposed to have taken it
  • If more than 12 hours passed, simply skip the dose and continue with the course as usual
  • Never take two pills to compensate for the missed dose
  • Advice on when to commence treatment will be provided in the patient information leaflet and will vary individually

What are Kliovance side effects?

If you experience any side effects when using Kliovance, you should contact your doctor as soon as possible. However, in order to differentiate between the potentially dangerous side effects and those which are uncomfortable but otherwise benign, you should get familiar with the full list of documented side effects. You can find this list in the official patient information leaflet.

Below, we will provide you with excerpt from that list. This should make it immediately clear that you shouldn’t be using the text that follows as a substitute for official information on the topic and it can definitely not replace consultations with a doctor. Instead, the list provided here will help you get a better idea of which side effects might occur, in what percentage of those using Kliovance and also which side effects are more dangerous than others.

Side effects that will require you to immediately contact your doctor include:

  • Allergic reaction
  • Heart attack
  • Stroke
  • Blood clot
  • High blood pressure
  • Liver disease
  • Signs of breast, cervical or ovarian cancer

Other documented side effects include:

Frequency of occurrence Side effects
Very common (1 in 10 users or more) Breast pain or tenderness, unexplained vaginal bleeding
Common (1 in 10 users or less) Headaches, weight gain, fluid retention, inflammation of the vagina, fungal infections, depression, nausea, swelling of the breasts, back pain, uterine fibroids, mood swings
Uncommon (1 un 100 users) Bloating, abdominal pain, acne, hair loss, hives, excessive hair growth, inflammation of a vein, leg cramps, anxiety
Rare (1 in 1000 users) Blood clots in the blood vessels of the legs or the lungs