The active substance in Colrefuz tablets is colchicine. Kolkisin has anti-inflammatory and soothing effect in acute urinary insufficiency attacks. The drug works by preventing inflammation cells and uric acid crystals accumulating in the joints. Kolkisin is used to relieve the pain in an acute attack and to prevent urinary retention. Combining colchicine with other anti-gout drugs may be appropriate.1

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Colchicine Dosage

Prevention of urinary retention attacks:
If colicitis is used prophylactically, the dose in adults is usually 1 tablet of 0.5 mg 1-3 times daily. Treatment may continue after 12 hours, with max 0.5 mg at 8-hour intervals until symptoms are alleviated. It should not be taken more than> 6 mg during the treatment period. After completion of treatment, no new treatment course should be initiated for at least 72 hours.

Treatment options for acute outbreak

In case of acute gout outbreak, colichicine is often higher than in preventive treatment, and then the dose is reduced. Best effect is achieved at early treatment during the attack. Physicians decide in consultation with you what exact dose you will have and how long your treatment should last.2

Colchicine tablets should be swallowed whole with a glass of water.

Interactions with Colchicine

Kolkisin is a substrate for CYP3A4 and P-gp. Concomitant use of CYP3A4 or P-gp inhibitors increases the concentration of calcicin in the blood, which may cause toxicity, including death. If treatment with P-gp inhibitors or moderate / strong CYP3A4 inhibitors is necessary in normal renal and hepatic function, a reduction in the cholicase dose or discontinuation of the colchicine treatment is recommended. Cochalin dose should be reduced to ¼ in combination with P-gb inhibitors or strong CYP3A4 inhibitors and halved in combination with moderate CYP3A4 inhibitors. Caution is advised when using medicines that may affect blood levels or adversely affect your liver and / or kidney function. Cimetidine and tolbutamide reduce the metabolism of the colchicine, resulting in increased plasma levels. Grapefruit juice can increase the plasma levels of colchicine. Should not be taken at the same time. Reversible malabsorption of cyanocobalamin (Vitamin B12) may be induced by altered function of the intestinal mucosa. The risk of myopathy and rhabdomyolysis increases in combination with statins, fibrates, ciclosporin or digoxin


Do not use Colichine if:

  • If you are allergic to colchicine or any of the other ingredients of this medicine
  • If you have severe blood disease
  • If you are pregnant
  • If you are breastfeeding
  • If you are a woman of childbearing age, unless you use safe contraception
  • If you have severe kidney or liver problems
  • If you undergo hemodialysis
  • If you have kidney or liver problems and you are taking certain other medicines

Side effects

Like all other medicines, this medicine can cause side effects, although not everybody gets them.

Stop using Colchicine tablets and contact a doctor, emergency department or hospital immediately if you notice any of the following side effects:

  • Nausea
  • vomiting
  • abdominal pain and diarrhoea.
  • Symptoms like fever, mouth inflammation, sore throat, prolonged bleeding, bruising or skin problems. This may indicate that you have severe blood problems as a result of decreased bone marrow function. The frequency of these side effects is unknown.

Other side effects that have become familiar with unknown frequency are:

  • Nerve inflammation, which can cause pain, weakness, tingling or numbness
  • nerve damage
  • Bleeding in the gastrointestinal tract
  • liver Injury
  • Hair Loss
  • Rash
  • Pain or weakness in the muscles
  • Abnormal muscle breakdown, which can lead to kidney problems
  • kidney damage
  • Absence of menstrual bleeding
  • Painful menstrual periods
  • Reduced ability to produce sperm cells
  • If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor, pharmacist or nurse.


The prescribed dose must not be exceeded. Narrow therapy window. Administration should be discontinued for symptoms such as nausea, vomiting, abdominal pain or diarrhea. May cause severe bone marrow depression. Changes in blood levels may occur gradually or very suddenly. In particular aplastic anemia has high mortality. Regular blood tests are required. In the event of signs or symptoms of blood dysfunction such as fever, stomatitis, sore throat, prolonged bleeding, bruising or skin reactions, treatment should be discontinued and full hermatological examination should be undertaken immediately. Use with caution in cardiovascular disease, gastrointestinal disease, abnormalities in blood values, in elderly or debilitated patients. 3


Contains lactose and should not be used in galactose intolerance, patch lactase deficiency or glucose-galactose malabsorption.

Driving and using machines

Small impact. Risk of drowsiness and dizziness should be taken into account.


  1. Read more about the medicine – NHS
  2. Gout attack – NHS